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EPITARGET

Targets and biomarkers for

antiepileptogenesis

Short Facts


In order to someday be able to prevent the development of epilepsy, the multidisciplinary research project EPITARGET is focused on the process leading to epilepsy (epileptogenesis) in adults. The main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and the development of seizures. The central premise and vision is that by using a combinatorial approach to identify appropriate biomarkers that allow the prediction of the disease and by developing effective anti-epileptogenic therapeutics, patients at risk can be treated before they even have epilepsy.

The project will focus on:

  • identifying novel biomarkers and their combinations for epileptogenesis after potentially epileptogenic brain insults in clinically relevant animal models, such as traumatic brain injury (TBI) and status epilepticus (SE);
  • exploring multiple basic mechanisms of epileptogenesis and their mutual interactions;
  • and translating these findings towards the clinic by validating biomarkers in human samples accessible to the consortium.

The EPITARGET consortium consists of 18 partners from 9 different European countries and Israel and is coordinated by Prof. Mérab Kokaia from the Lund University in Sweden.

Prof. Mérab Kokaia

Director of Epilepsy Center
Department of Clinical Sciences
Lund University Hospital, Sweden

Merab.Kokaia@med.lu.se